Therefore, withdrawal should be gradual, until very little actual medication is being applied. Ībrupt withdrawal of highly potent corticosteroids, such as clobetasol for psoriasis can cause a much more severe case of the psoriasis to develop. The cause of the rebound is unclear however, since around a third of people with COVID-19 experience a symptom rebound regardless of treatment. In May, CDC even issued a health alert informing physicians about "Paxlovid rebounds", which received attention when US president Joe Biden experienced a rebound. In 2022, reports of viral RNA and symptom rebound in people with COVID-19 treated with Paxlovid were published. Rebound hypertension, above pre-treatment level, was observed after clonidine, and guanfacine discontinuation.Ĭontinuous usage of topical decongestants ( nasal sprays) can lead to constant nasal congestion, known as rhinitis medicamentosa.Īnother example of pharmaceutical rebound is a rebound headache from painkillers when the dose is lowered, the medication wears off, or the drug is abruptly discontinued. Sudden and severe emergence or re-emergence of psychosis may appear when antipsychotics are switched or discontinued too rapidly. Many antidepressants, including SSRIs, can cause rebound depression, panic attacks, anxiety, and insomnia when discontinued. Up to a third of ADHD children experience a rebound effect when methylphenidate is withdrawn. Rebound effects from stimulants such as methylphenidate or dextroamphetamine include stimulant psychosis, depression and a return of ADHD symptoms but in a temporarily exaggerated form.
Daytime rebound effects are not necessarily mild but can sometimes produce quite marked psychiatric and psychological disturbances. Quazepam, due to its selectivity for type1 benzodiazepine receptors and long half-life, does not cause daytime anxiety rebound effects during treatment, showing that half-life is very important for determining whether a nighttime hypnotic will cause next-day rebound withdrawal effects or not. One drug which seems to be commonly associated with these problems is triazolam, due to its high potency and ultra short half life, but these effects can occur with other short-acting hypnotic drugs.
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Another example is early morning rebound insomnia which may occur when a rapidly eliminated hypnotic wears off which leads to rebounding awakeness forcing the person to become wide awake before he or she has had a full night's sleep. Rebound phenomena do not necessarily only occur on discontinuation of a prescribed dosage. ĭaytime rebound effects of anxiety, metallic taste, perceptual disturbances which are typical benzodiazepine withdrawal symptoms can occur the next day after a short-acting benzodiazepine hypnotic wears off.
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Rebound depression may appear to arise in patients previously free of such an illness. Common medicines known to cause this problem are eszopiclone, zolpidem, and anxiolytics such as benzodiazepines and which are prescribed to people having difficulties falling or staying asleep. Occasionally, this insomnia may be worse than the insomnia the drug was intended to treat. Therefore, when a person has stopped taking the medication and is 'rebounding' from its effects, they may experience insomnia as a symptom of withdrawal. Regular use of these substances can cause a person to become dependent on its effects in order to fall asleep. Rebound insomnia is insomnia that occurs following discontinuation of sedative substances taken to relieve primary insomnia. In the case of re-emergence, the severity of the symptoms is often worse than pretreatment levels. The rebound effect, or pharmaceutical rebound phenomenon, is the emergence or re-emergence of symptoms that were either absent or controlled while taking a medication, but appear when that same medication is discontinued, or reduced in dosage. The rebound effect, or rebound phenomenon, is the emergence or re-emergence of symptoms that were either absent or controlled while taking a medication, but appear when that same medication is discontinued, or reduced in dosage. For the energy conservation term, see Rebound effect (conservation). This article is about the pharmacological term.
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